USA’s GM Fabiano Caruana (2805) defended accurately and eventually beat Chinese GM Hou Yifan (2676) to take the lead going into the last round.
Co-leader GM Dieter Nisipeanu (2654) of Germany could only hold Russian GM Vladimir Kramnik (2783). He needs to beat Caruana in the final round to win the tournament while a draw would suffice for the American.
Standings after Round 6:
| Rank | Name | Score | Elo |
| 1 | Caruana, Fabiano | 4.5/6 | 2805 |
| 2 | Nisipeanu, Liviu-Dieter | 4.0/6 | 2654 |
| 3 | Kramnik, Vladimir | 3.5/6 | 2783 |
| 4 | So, Wesley | 3.0/6 | 2778 |
| 5 | Naiditsch, Arkadij | 2.5/6 | 2722 |
| 6 | Nepomniachtchi, Ian | 2.5/6 | 2720 |
| 7 | Hou, Yifan | 2.0/6 | 2676 |
| 8 | Meier, Georg | 2.0/6 | 2654 |