GM Fabiano Caruana scored an important victory over GM Alexander Onischuk in the 6th round of the U.S. Championship 2016, thus jumping into sole lead with 5/6. Caruana, playing the White side of a Ruy Lopez, dominated the proceedings right from the start and went on to win an impeccable game.
Meanwhile, the high-voltage encounter between GM Wesley So and GM Hikaru Nakamura ended in a draw. A popular line of the French Defence gave rise to an interesting battle. However, the queens were exchanged soon and on the 28th move, Wesley So decided to play it safe by opting for a perpetual.
Results
| Wesley So | ½-½ | Nakamura |
| Caruana | 1-0 | Onischuk |
| Kamsky | ½-½ | Robson |
| Shankland | 0-1 | Shabalov |
| Akobian | ½-½ | Lenderman |
| Chandra | ½-½ | Xiong |